Trexate 2.5mg Tablets (10s)

Description

Trexate contains methotrexate, a prescription medicine that suppresses abnormal immune activity and rapidly dividing cells. It is used under specialist supervision for selected inflammatory, autoimmune, dermatologic, and malignant conditions.

• Manufacturer Name: Pharmasol
• Drug Class: Antimetabolite; folate antagonist; disease-modifying antirheumatic drug; immunosuppressant
• Dosage Form: Immediate-Release Tablet
• Storage: Store at room temperature in the original package, protected from moisture and excessive heat. Keep out of reach of children and handle only as directed.
• Pack Size: Strip of 10 Tablets

Trexate 2.5mg Tablets (10s) Available Online in Pakistan

Dwatson offers Trexate 2.5mg Tablets (10s) at Rs.84.4, with fast, discreet delivery across Pakistan.

Ingredients

• Methotrexate 2.5 mg per tablet

Benefits

• Rheumatoid arthritis and other selected inflammatory autoimmune disorders
• Psoriasis and psoriatic arthritis requiring systemic treatment
• Selected cancers and hematologic malignancies, according to specialist protocols
• Other specialist-directed uses, including certain ectopic pregnancy protocols

Usage & Safety

For Adult

• Take only according to the prescriber's written instructions; low-dose treatment is usually taken once weekly, not daily.
• Dosage varies by indication and response; for inflammatory conditions, treatment commonly begins at a low weekly dose and is adjusted under medical supervision.
• Swallow tablets with water, preferably on the same day each week. Do not change the weekly schedule or dose without medical advice.
• Regular blood counts, liver function, and kidney function monitoring are generally required.
• Folic acid may be prescribed separately to reduce adverse effects; follow the prescribed schedule.

For Children

• Pediatric use requires specialist supervision and dosing is usually calculated by body-surface area or weight according to the condition.
• For some inflammatory diseases, dosing may be approximately 10 mg/m² once weekly, but the prescribed regimen may differ.
• No universal minimum weight applies to all indications; safety and dosing depend on age, body size, kidney and liver function, and diagnosis.
• Do not use in children for self-treatment or without specialist monitoring.

Side Effects

• Common: nausea, vomiting, abdominal discomfort, diarrhea, reduced appetite, mouth ulcers, headache, tiredness, and hair thinning
• Laboratory abnormalities: reduced blood-cell counts and increased liver enzymes
• Serious: unusual bleeding or bruising, severe infection, persistent fever, severe mouth sores, yellowing of the skin or eyes, severe skin reactions, kidney problems, or lung inflammation
• Seek urgent medical attention for breathing difficulty, severe rash, signs of infection, or symptoms of severe toxicity

Contraindications

• Pregnancy or attempts to conceive, unless specifically directed within a specialist-managed protocol
• Breastfeeding during treatment, particularly with prolonged or high-dose therapy
• Hypersensitivity to methotrexate or any tablet ingredient
• Significant liver disease, severe kidney impairment, severe blood-cell disorders, or active serious infection
• Immunodeficiency or significant bone-marrow suppression
• Inability to follow the once-weekly dosing schedule or required laboratory monitoring
• Do not use concurrently with trimethoprim or trimethoprim-sulfamethoxazole unless specifically managed by a specialist

Precautions & Warnings

• Trimethoprim, trimethoprim-sulfamethoxazole, chloramphenicol, and other medicines that suppress bone marrow may increase blood toxicity.
• Nonsteroidal anti-inflammatory drugs, aspirin, penicillins, sulfonamides, proton-pump inhibitors, and other medicines that affect kidney clearance may increase methotrexate toxicity.
• Other hepatotoxic or nephrotoxic medicines, including some antibiotics and anticonvulsants, may increase the risk of liver or kidney injury.
• Live vaccines may cause infection or reduced vaccine safety; consult the prescriber before vaccination.
• Avoid alcohol because it may increase liver toxicity. Discuss all medicines, vitamins, herbal products, and supplements with the prescriber.

Pregnancy

• Methotrexate can cause fetal harm, pregnancy loss, and birth defects and is contraindicated during pregnancy for routine treatment.
• People who can become pregnant should use effective contraception during treatment and follow the prescriber's advice regarding the required washout period before conception.
• Men and women planning pregnancy should discuss methotrexate discontinuation with a specialist before attempting conception.
• Breastfeeding is generally not recommended during ongoing methotrexate treatment; seek specialist advice before resuming.