Co Purpal 500mg/20mg Tablets (28s)

Description

Co Purpal is a prescription fixed-dose combination tablet containing naproxen and esomeprazole. It is used to relieve inflammation and pain while helping reduce the risk of naproxen-related gastric irritation and ulcers.

• Manufacturer Name: Dyson Research
• Drug Class: Nonsteroidal anti-inflammatory drug (NSAID) with proton pump inhibitor
• Dosage Form: Tablet
• Storage: Store at room temperature in a dry place, protected from heat, moisture, and direct light. Keep out of reach of children and do not use after the expiry date.
• Pack Size: Pack of 28

Co Purpal 500mg/20mg Tablets (28s) Available Online in Pakistan

Dwatson offers Co Purpal 500mg/20mg Tablets (28s) at Rs.1200, with fast, discreet delivery across Pakistan.

Ingredients

• Naproxen 500 mg
• Esomeprazole 20 mg

Benefits

• Relief of pain and inflammation associated with osteoarthritis and rheumatoid arthritis.
• Relief of musculoskeletal and other inflammatory pain when an NSAID is clinically appropriate.
• Helps reduce the risk of gastric and duodenal ulcers associated with continued naproxen treatment.

Usage & Safety

For Adult

• Take only as prescribed by a healthcare professional.
• A commonly used adult regimen for naproxen 500 mg and esomeprazole 20 mg combination products is one tablet twice daily.
• Swallow the tablet whole with water; do not crush, chew, or split it unless specifically instructed.
• Use the lowest effective dose for the shortest appropriate duration.
• Take before meals as directed, and avoid taking additional naproxen or other NSAIDs unless advised by a healthcare professional.

For Children

• Not routinely recommended for children or adolescents unless specifically prescribed by a specialist.
• Safety and dosing have not been established for general pediatric use with this fixed-dose combination.
• Do not use in children weighing less than 50 kg unless directed by a pediatric specialist.

Side Effects

• Common effects may include indigestion, stomach pain, nausea, vomiting, heartburn, diarrhea, constipation, headache, dizziness, and gas.
• Esomeprazole may cause abdominal discomfort, dry mouth, or changes in bowel habits.
• Seek urgent medical attention for black or bloody stools, vomiting blood, severe abdominal pain, chest pain, shortness of breath, swelling, severe skin rash, facial swelling, or difficulty breathing.
• Serious risks include gastrointestinal ulceration or bleeding, kidney injury, liver problems, severe allergic reactions, cardiovascular events, and serious skin reactions.
• Long-term proton pump inhibitor use may be associated with low magnesium, vitamin B12 deficiency, bone fractures, and certain intestinal infections.

Contraindications

• Do not use in people with allergy to naproxen, esomeprazole, other proton pump inhibitors, aspirin, or other NSAIDs.
• Contraindicated in patients with a history of NSAID-associated asthma, urticaria, or allergic reactions.
• Do not use in active stomach or intestinal ulcer, gastrointestinal bleeding, or a history of recurrent NSAID-related bleeding.
• Avoid in severe heart failure, severe kidney disease, or severe liver disease unless specifically supervised by a specialist.
• Do not use for pain around coronary artery bypass graft surgery.
• Avoid during the third trimester of pregnancy.
• Use cautiously in older adults and in people with hypertension, heart disease, previous ulcer disease, inflammatory bowel disease, dehydration, or bleeding disorders.

Precautions & Warnings

• Do not combine with other NSAIDs, including ibuprofen, diclofenac, aspirin at analgesic doses, ketoprofen, or celecoxib, unless prescribed.
• Use caution with anticoagulants and antiplatelet medicines such as warfarin, apixaban, rivaroxaban, clopidogrel, and aspirin because bleeding risk may increase.
• Corticosteroids, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and alcohol may further increase gastrointestinal bleeding risk.
• Naproxen may interact with ACE inhibitors, angiotensin receptor blockers, diuretics, lithium, methotrexate, cyclosporine, tacrolimus, and some medicines for high blood pressure.
• Esomeprazole may affect medicines whose absorption depends on stomach acidity and may interact with clopidogrel, digoxin, high-dose methotrexate, phenytoin, diazepam, and certain antiretroviral medicines.
• Tell the healthcare professional about all prescription medicines, over-the-counter products, and supplements before use.

Pregnancy

• Ask a healthcare professional before use during pregnancy.
• Avoid use during the third trimester because naproxen may affect the fetal cardiovascular system, kidneys, and labor.
• Use during the first and second trimesters only if clearly needed and prescribed.
• Naproxen and esomeprazole may pass into breast milk; consult a healthcare professional before breastfeeding while using this medicine.